Ents had aneurysm PED therapy and six (19.4 ) sufferers had extra or intracranial carotid angioplasty and stenting. There have been no important variations in the variety of individuals undergoing each and every process between therapy groups. A total of eight (9.3 ) hemorrhagic complications had been observed. Hemorrhages had been noticed in two (3.6 ) sufferers treated with aspirin/clopidogrel DAPT and in six (19.four ) sufferers treated with aspirin/prasugrel DAPT (p.02) (table 2). Excluding a single patient in the aspirin/prasugrel DAPT group who skilled a basilar artery perforation, the difference in hemorrhage rates in between the DAPT groups trended towards significance but didn’t reach statistical significance (p.09). Inside the aspirin/clopidogrel group, hemorrhage was observed in one particular (33.three ) patient treated with Onyx aneurysm embolization and a single (14.three ) patient treated with aneurysm PED placement. For the aspirin/prasugrel group, hemorrhagic events were seen in one (22.6 ) patient treated with aneurysm coil embolization, one particular (12.5 ) patient treated with aneurysm stent assisted coil embolization, two (22.two ) sufferers treated with aneurysm PED placement, one particular (33.three ) patient treated with extracranial carotid angioplasty and stenting, and one (50 ) patient treated with intracranial carotid angioplasty and stenting (table two). No statistically considerable variations in hemorrhage prices have been observed in between therapy groups for every procedure. There have been no substantial differences in the price of neurological (eg, intracerebral) and nonneurological (eg, extracerebral) hemorrhage in between remedy groups (p0.13 in both circumstances). Within the aspirin/clopidogrel group, one particular patient seasoned a groin hematoma with retroperitoneal extension requiring a blood transfusion after Onyx embolization of a rightTablePatient demographics and procedures performedn 55 31 Gender (n ( )) 11 M (20) 44 F (80) 7 M (23) 24 F (77) Age (years) 61.2612.4 59.4614.8 0.565 Anx coil (n ( )) 17 (30.9) five (16.1) 0.198 Anx stent coil (n ( )) 22 (40.0) eight (25.8) 0.241 Anx Onyx embo (n ( )) three (five.five) 3 (9.7) 0.663 Anx PED (n ( )) 7 (12.7) 9 (29.0) 0.084 Extracranial carotid angioplasty and stenting (n ( )) three (5.five) 6 (19.4) 0.065 Intracranial carotid angioplasty and stenting (n ( )) two (3.six) 0 (0) e dAVF coil embo (n ( )) 1 (1.eight) 0 (0) eTreatment group Aspirin and clopidogrel Aspirin and prasugrel p ValueAnx, aneurysm; dAVF, dural arteriovenous fistula; embo, embolization; PED, pipeline embolization device.1-(Quinolin-2-yl)ethanone Purity J NeuroIntervent Surg 2013;5:33743.Potassium trichloroammineplatinate(II) manufacturer doi:ten.1136/neurintsurg2012Clinical neurologyTable 2 Hemorrhagic complications between therapy groupsTotal (n ( )) two (3.6) 6 (19.4) 0.02 Anx coil (n ( )) 0 (0) 1 (20) 0.24 Anx stent coil (n ( )) 0 (0) 1 (12.five) 0.27 Anx Onyx embo (n ( )) 1 (33.PMID:23659187 three) 0 (0) e Anx PED (n ( )) 1 (14.3) 2 (22.two) 1.0 Extracranial carotid angioplasty and stenting (n ( )) 0 (0) 1 (33.three) e Intracranial carotid angioplasty and stenting (n ( )) 0 (0) 1 (50) e dAVF coil embo (n ( )) 0 (0) 0 (0) eTreatment group Aspirin and clopidogrel Aspirin and prasugrel p ValueAnx, aneurysm; dAVF, dural arteriovenous fistula; embo, embolization; PED, pipeline embolization device.paraclinoid aneurysm. An additional patient, treated with PED for any left cavernous carotid aneurysm, presented 5 days after remedy with headache and was identified to have an anterior interhemispheric subarachnoid hemorrhage. In the aspirin/prasugrel group, 1 patient had a basilar artery perforation with subarachnoid hemorrhage, intraventricular he.