The final manuscript. Authors’ data Not applicable.Xu et al. BMC Ophthalmology (2015) 15:Page 7 ofAvailability of information and supplies Not applicable. Acknowledgments I do not have someone to acknowledge. Funding This short article was from the National Natural Science Foundation of China: The function and mechanism of innate immune mediated by Dectin-1 in fungal keratitis (NO:81170825). This short article was supported by National Natural Science Foundation of China (No.81170825:Role of Dectin-1in the innate immune inflammation of Fungal Keratitis; No.81470609:Mechanism of LOX-1 in anti-fungalinnate immune of fungal keratitis); Shandong province natural science foundation (No. ZR2013HQ007: Role of Interlein33/ST2 signaling inside the immune inflammation of Fungal Keratitis; No. ZR2012HZ001: Theinfluence of AQP1 on Crystal protein as well as the study of targeted therapy within the pathogenesis of senilecataract ); the Specialized Study Fund for the Doctoral Program of Higher Education, 2012(No.20123706110003: Function of Mincle inside the innate immune inflammation of Fungal Keratitis). Received: 24 November 2014 Accepted: ten SeptemberReferences 1. Zhao J, Wu X-y, Fu-Shin X, Yu. Activation of Toll-like receptors two and four in Aspergillus fumigatus keratitis. Innate Immunity. 2009;15:1558. two. Leal Jr SM, Cowden S, Hsia Y-C, Ghannoum MA, Momany M, Pearlman E. Distinct Roles for Dectin-1 and TLR4 inside the Pathogenesis of Aspergillus fumigatus Keratitis. PLoS Pathogens. 2010;six:e1000976. 3. Li N, Che CY, Hu LT, Lin J, Wang Q, Zhao GQ. Effects of COX-2 inhibitor NS-398 on IL-10 expression in rat fungal keratitis.Price of 2-Amino-4-bromo-6-fluorobenzaldehyde Int J Ophthalmol.2059140-61-1 site 2011;four(two):1160.PMID:23849184 four. Xie J, Guo L, Ruan Y, Zhu H, Wang L, Zhou L, et al. Laminarin-mediated targeting to Dectin-1 enhances antigen-specific immune responses. Biochemical and Biophysical Research Communications. 2010;391:9582. 5. Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, et al. Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol. 2004;76:864. 6. Li N, Zhao GQ. Mechanism of the immune response to keratomycosis. Chin J Ophthalmol. 2011;47:3781. 7. Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, et al. Dectin-1 is expected for beta-glucan recognition and control of fungal infection. J Nat Immunol. 2007;8(1):31. eight. Mohlopheni J M,Ann M K, Gordon D B. Dectin-1: a part in antifungal defense and consequences of genetic polymorphisms in humans. Mammalian Genome. 2011;22(1-2):555 9. Goodridge HS, Simmons RM, Underhill DM. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol. 2007;178:31075. 10. Gross O, Gewies A, Finger K, Sch er M, Sparwasser T, Peschel C, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006;442:651. 11. Slack EC, Robinson MJ, Hernanz-Falcon P, Brown GD, Williams DL, Schweighoffer E, et al. Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. Eur J Immunol. 2007;37:16002. 12. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by Dectin-1 and Toll-like receptor two. J Exp Med. 2003;197(9):11077.Submit your subsequent manuscript to BioMed Central and take full advantage of:Handy online submission Thorough peer evaluation No space constraints or colour.
